12/16/2023 0 Comments Biote dim sgs side effects![]() It may help reduce hormonal acne and menopause symptoms, and promote weight loss. Summary: DIM is most effective in helping maintain hormonal balance, especially between estrogen and testosterone. There have been few clinical trials, and those have mostly shown little or no significant effect from DIM supplementation on women with a high risk of breast cancer ( 18). Keep in mind that all of these studies have only been done in the lab. Other test-tube studies have found that DIM supplementation for 30 days showed anti-cancer activities in cancer cells related to prostate, breast, endometrial, colorectal, pancreatic and leukemia ( 15).Īnother powerful way it works against cancer is via its anti-inflammatory and antioxidant effects.īoth I3C and DIM can inhibit a pathway linked to inflammation and reduce oxidative stress in the process ( 16, 17). It also activates an enzyme called AMPK-activated protein kinase (AMPK), which helps induce apoptosis (cell death) in prostate cancer cells ( 14). One study on postmenopausal women with a history of early-stage breast cancer found that taking a DIM supplement for 30 days increased the metabolism of one of the “good” estrogens, 2-hydroxyestrone (2-OHE1) ( 11).Īnother found that it inhibited the growth of breast cancer cells in mouse models ( 12).ĭIM has also shown the ability to induce death and autophagy (cell cleansing) in human prostate cancer cells, and even help reduce tumor growth in vivo ( 13). There’s some promising research around DIM and cancer, particularly in the breast and prostate. While little has been studied on the direct impact between DIM and weight in humans, we do know that obesity is often linked with hormonal imbalances. Mice on a high-fat diet showed a reduced risk of obesity and decreased fat tissue when injected with DIM ( 10). The mice injected with I3C showed a decrease in body weight and fat accumulation even when consuming a high-fat diet ( 9).Ī more recent study on mice found even more promising results with the use of DIM. One study on mice tested I3C and its effect on weight. Women typically hold this fat in their hips and thighs ( 8).Īlong with balancing estrogen, DIM and its precursor, indole-3-carbinol (I3C), can also suppress adipogenesis, which is the process of producing new fat cells. So, the more fat you have, the more estrogen you make. To make matters worse, both men and women produce estrogen in their fat tissues. Too much or too little estrogen can cause the body to store more fat ( 7). AcneĭIM’s balancing effect on estrogen can also help shed some unwanted pounds. It may also work as a potent anti-inflammatory and antioxidant. In general, DIM’s ability to prevent large increases or decreases in estrogen can help with a number of issues, including acne, menopause symptoms, weight gain and even cancer. DIM Supplement BenefitsĭIM is most effective in helping maintain hormonal balance, especially between estrogen and testosterone in both men and women. Supplements can be taken to provide a much higher dosage of DIM than you’ll likely get from just consuming vegetables. DIM can help support detoxification and help balance hormones. Summary: Diindolymethane (DIM) is a natural compound found in cruciferous vegetables, including cabbage, broccoli and Brussels sprouts. So, if you’re considering taking a DIM supplement, don’t forget to continue eating your veggies, too! On the other hand, a DIM supplement will lack all of the other beneficial nutrients-including fiber, vitamins and minerals-that come with consuming whole cruciferous vegetables.įor example, another glucobrassicin found in broccoli was shown to be more effective in inhibiting colon cancer than I3C and DIM ( 3). Low-temperature steaming for 3-4 minutes may be the best way to both reduce those goitrogenic components and preserve the compounds that transform into DIM in your body ( 2).īut supplements can offer you a much higher dosage of DIM than you’d likely be able to consume in vegetables. That said, those who have an underactive thyroid and are also deficient in iodine may need to be especially careful of the amount of these vegetables they consume raw. However, this is typically only the case when consumed in very large quantities. Cooking, boiling or microwaving this group of vegetables actually reduces the absorption of glucobrassicin and DIM in the body ( 1).īut if you take away the heat and eat your cruciferous vegetables raw or even fermented (like with sauerkraut), you may run into another possible issue: goitrogens.Ĭruciferous vegetables are naturally high in goitrogens, which can potentially impact thyroid production. First of all, any heat can lessen the impact of DIM. ![]()
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